Professional Manufacturer Supply Riociguat

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP
• Suitable for: Adult
• State: Solid
• Purity: >99%
• Model NO.: Riociguat
• Product Name: Riociguat
• Botanical Name: Adempas
• Brand: Zebrago
• Appearance: White Powder
• Test Method: HPLC
• Molecular Formula: C38h72n2o12
• Use: Phamaceutical Intermediates
• Grade: Phamaceutical Grade
• Function: Phamaceutical Intermediates
• CAS No: 625115-55-1
• Storage: Store in a Cool and Dry Place
• Free Sample: 10 Grams Available
• Apply: for Pah
• Solubility: Soluble in Acetone, Very Slightly Soluble in Hot
• Shipment: by FedEx DHL
• Transport Package: Drum
• Specification: 99% Min
• Trademark: Zebrago
• Origin: China
• HS Code: 2932999099
• Production Capacity: 1000kg/Year

Product Description

Name	Riociguat
Synonyms	N-[4,6-Diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-N-methylcarbamic acid methyl ester
Brand	Zebrago
Molecular Formula	C20H19FN8O2
Molecular Weight	422.42
CAS NO	625115-55-1

 Riociguat is a stimulant of soluble guanine cyclase (sGC), an enzyme in the cardiopulmonary system and a receptor for nitric oxide (NO).When NO binds to sGC, enzymes catalyze the synthesis of the signaling molecule cyclic GMP (cGMP), which plays an important role in the regulation of vascular tension, proliferation, fibrosis and inflammation.Pulmonary hypertension is associated with endothelial dysfunction, impaired nitric oxide synthesis, and inadequate stimulation of the no-sgc-cgmp pathway.Riociguat has a dual role model.It synthesizes GC to endogenous NO by stabilizing NO-sGC binding.Riociguat also stimulates directly through different binding sites independent of NO.Riociguat stimulates the no-sgc-cgmp pathway and leads to increased cGMP generation with subsequent vasodilatation.

Certificate of Analysis

Batch Number		Z20190412001
Production Date		2019.04.12
Batch Quantity		80 KGS
Item	Test Standard		Testing Result
Appearance	Powder		Complies
Color	White fine Powder		Complies
Particle Size	100% pass 80 mesh		Complies
Oder	Characteristic		Complies
Taste	Characteristic		Complies
Loss on Drying	≤5.0%		2.20%
Residue on Ignition	≤0.1%		0.05%
Residual acetone	≤0.1%		Complies
Residual Ethanol	≤0.5%		Complies
Heave Mentals	≤10ppm		Complies
Na	≤0.1%		<0.1%
Pb	≤3 ppm		Complies
Total Plate	<1000CFU/g		Complies
Yeast & Mold	<100 CFU /g		Complies
E. Coli	Negative		Complies
Salmonella	Negative		Complies
Conclusion: Conform with USP Standard

Storage:Closed container. dry & cool. keep away from moisture &strong light
Shelf life:24 Months  

 

Shipping Options as follows
 

EMS	Around 7-10 working days
DHL	Around 3-5 working days
Fedex	Around 4-6 working days
TNT	Around 6-7 working days
By Air	Around 5-7 working days
By Sea	Around 15-30 working days

     

Perfect After-Sales Service

1. Product Pictures Showing
2. Shipment Tracking Number
3. Promptly Following Tracking Status
4. Delivery Notice
5. Product Quality Following
6. Product Feedback
7. Follow-up Improvement Suggestion

FAQ