Anti Hair Loss Darolutamide with CAS 1297538-32-9

• Powder: Yes
• Customized: Non-Customized
• Certification: GMP, ISO 9001, USP
• Suitable for: Adult
• State: Solid
• Purity: >99%
• Model NO.: Darolutamide
• Product Name: Darolutamide
• Botanical Name: ODM 201
• Active Ingredient: Darolutamide
• Appearance: White Powder
• Test Method: HPLC
• Molecular Formula: C38h72n2o12
• Use: Dermatology
• Grade: Phamaceutical Grade
• Function: Pyridine Derivative
• CAS No: 1297538-32-9
• Storage: Store in a Cool and Dry Place
• Free Sample: 10 Grams Available
• Apply: Pharmaceutical Raw Intermediates
• Solubility: Soluble in Acetone, Very Slightly Soluble in Hot
• Shipment: by FedEx DHL
• Transport Package: Drum
• Specification: 99% Min
• Trademark: Zebrago
• Origin: China
• HS Code: 2932999099
• Production Capacity: 1000kg/Year

Product Description

 

 

 

Product Name	Darolutamide
Purity	99%
CAS No.	1297538-32-9
Molecular Formula	C19H19ClN6O2
Molecular Weight	398.85
Appearance	white powder
Shelf life	24 months under the previously mentioned conditions.
Storage	Store in a cool dry place, avoiding sunlight directly.

 

ODM-201, also known as Darolutamide, is a new-generation, potent and selective androgen receptor (AR) inhibitor which is potential useful for treatment of castration-resistant prostate cancer (CRPC). ODM-201 is a full and high-affinity AR antagonist that, similar to second-generation antiandrogens enzalutamide and ARN-509. Importantly, ODM-201 also blocks the activity of the tested mutant ARs arising in response to antiandrogen therapies, including the F876L mutation that confers resistance to enzalutamide and ARN-509. In addition, ODM-201 reduces the growth of AR-overexpressing VCaP prostate cancer cells both in vitro and in a castration-resistant VCaP xenograft model. ODM-201 overcomes resistance to AR-targeted therapies by antagonizing both overexpressed and mutated ARs. ODM-201 is currently in a phase 3 trial in CRPC.

 

ODM-201 is a potent and full antagonists for human AR (hAR) with IC50 values of 26 nM by transactivation assays in AR-HEK293 cells.
IC50 value: 26 nM (in AR-HEK293 cells)
Target: androgen receptor
in vitro: ODM-201 is a new-generation androgen receptor inhibitor targeting resistance mechanisms to androgen signaling-directed prostate cancer therapies. In competitive AR binding assays, the inhibition constant (Ki) values of ODM-201 were 11 nM. 
in vivo: ODM-201 inhibits tumor growth in a castration-resistant VCaP xenograft model in vivo. ODM-201 shows a significant antitumor activity with both doses, 50 mg/kg twice daily being more efficacious compared to castrated, untreated mice (p < 0.001).

Certificate of Analysis

Batch Number		Z20190412001
Production Date		2019.04.12
Batch Quantity		80 KGS
Item	Test Standard		Testing Result
Appearance	Powder		Complies
Color	White fine Powder		Complies
Particle Size	100% pass 80 mesh		Complies
Oder	Characteristic		Complies
Taste	Characteristic		Complies
Loss on Drying	≤5.0%		2.20%
Residue on Ignition	≤0.1%		0.05%
Residual acetone	≤0.1%		Complies
Residual Ethanol	≤0.5%		Complies
Heave Mentals	≤10ppm		Complies
Na	≤0.1%		<0.1%
Pb	≤3 ppm		Complies
Total Plate	<1000CFU/g		Complies
Yeast & Mold	<100 CFU /g		Complies
E. Coli	Negative		Complies
Salmonella	Negative		Complies
Conclusion: Conform with USP Standard

Storage:Closed container. dry & cool. keep away from moisture &strong light
Shelf life:24 Months  

 

Shipping Options as follows
 

EMS	Around 7-10 working days
DHL	Around 3-5 working days
Fedex	Around 4-6 working days
TNT	Around 6-7 working days
By Air	Around 5-7 working days
By Sea	Around 15-30 working days

     

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