| CAS No.: | 1094-61-7 |
|---|---|
| Formula: | C11h15n2o8p |
| EINECS: | 202-713-4 |
| Packaging Material: | HPMC |
| Storage Method: | Normal |
| Shelf Life: | 2 Years |
| Samples: |
|---|
| Customization: |
|---|
Suppliers with verified business licenses
Audited Supplier 
| Product Name | NMN |
| Production Method | Enzymatic method |
| Appearance | white powder |
| Active Ingredient | Nicotinamide Mononucleotide |
| Specification | 99% |
1.NMN converts to NAD by different enzymes in different subcellular compartments
Nicotinamide mononucleotide adenylyltransferase (NMNAT) is the central enzyme of the NAD biosynthetic pathway. The conversion of NMN to NAD+ is catalyzed by three enzyme isoforms-namely, NMN adenyltransferases (NMNATs) that are differentially localized (NMNAT1, nucleus; NMNAT2, Golgi, cytosol-facing; NMNAT3, mitochondria)
2.NMN increases NAD and delays cell death
When NMN was added to the culture medium for 1 h, its intracellular contents increased in both cell types (HeLa and U937 cells), indicating that the nucleotide readily permeates the plasma membrane. Accordingly, NAD contents increased in both HeLa and U937 cells exposed to NMN. NMN reduces NAD and ATP depletion in cells undergoing PARP-1 hyperactivation, significantly delaying cell death
1. Increases cellular energy In human cells,
NMN is available as a source of cellular energy. Mitochondria are intracellular powerhouses that produce ATP and carry out diverse functions for cellular energy metabolism. Mitochondrial ATP production and membrane potential require the universal cofactor nicotinamide adenine dinucleotide(NAD)[4]. NMN increases cellular energy by converting to NAD in cells.
2.Improves learning and memory
Amyloid-β (Aβ) oligomers are recognized as the primary neurotoxic agents in Alzheimer's disease (AD). Impaired brain energy metabolism and oxidative stress are implicated in cognitive decline in AD. NMN restored levels of NAD+ and ATP, eliminated the accumulation of reactive oxygen species (ROS) in the Aβ oligomer-treated hippocampal slices. The present study indicates that NMN could restore cognition in AD model rats. The beneficial effect of NMN is produced by ameliorating neuron survival, improving energy metabolism and reducing ROS accumulation
1.Slows down aging
2.Facilitates blood flow and heart health
3.Promotes proper brain functioning and protects from neurological disease
4.Fends off obesity and diabetes
Mechanism of Action of NMN
Calling on the salvage pathway
NAD+ metabolism is a dynamic redox cycle that functions to shuttle electrons throughout cells to maintain redox homeostasis and bioenergetics. NAD+ is synthesized through several pathways.
De novo synthesis of NAD+ accounts for a minority of the total NAD+ pool, while the majority of NAD+ comes from the salvage pathway
Certificate of Analysis
| Product: | Beta-NMN | Batch No: | 20190710 | ||
| Date of Manufacture: | 2019-7-10 | Quantity: | 15kg | ||
| Date of Certificate: | 2019-7-13 | CAS: | 1094-61-7 | ||
| Date of Expire: | 2021-7-9 | Specification: | 1kg/Aluminum foil bag | ||
| Items | Requirements | Results | |||
| Appearance | White Powder | Conformity | |||
| Appearance of solution (5% w/v in water) | Colorless | Conformity | |||
| Heavy Metals | <10.00 ppm | Conformity | |||
| PH | 2-5 | 3.0 | |||
| Arsenic | ≤1ppm | Conformity | |||
| As | ≤1ppm | Conformity | |||
| Water | ≤6% | 3.12% | |||
| Total Bilburden | <100CFU/g | Conformity | |||
| Sataph aureus | Negative | Negative | |||
| Moulds | <100CFU/g | Conformity | |||
| E.COLI | Negative | Negative | |||
| Salmonella | Negative | Negative | |||
| Purity (HPLC) | ≥99% | 99.60% | |||
| Conclusion: | Conforms to the requirement. | ||||
| Storage: | Keep it stored in low temperature, below 0ºC | ||||
Shipping Options as follows
| EMS | Around 7-10 working days |
| DHL | Around 3-5 working days |
| Fedex | Around 4-6 working days |
| TNT | Around 6-7 working days |
| By Air | Around 5-7 working days |
| By Sea | Around 15-30 working days |
Suppliers with verified business licenses
Audited Supplier 
){kind=link}
){kind=link}